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| Maya,Juan Diego; Orellana,Myriam; Ferreira,Jorge; Kemmerling,Ulrike; López-Muñoz,Rodrigo; Morello,Antonio. |
| There are approximately 7.8 million people in Latin America, including Chile, who suffer from Chagas disease and another 28 million who are at risk of contracting it. Chagas is caused by the flagellate protozoan Trypanosoma cruzi. It is a chronic disease, where 20%-30% of infected individuals develop severe cardiopathy, with heart failure and potentially fatal arrhythmias. Currently, Chagas disease treatment is more effective in the acute phase, but does not always produce complete parasite eradication during indeterminate and chronic phases. At present, only nifurtimox or benznidazole have been proven to be superior to new drugs being tested. Therefore, it is necessary to find alternative approaches to treatment of chronic Chagas. The current treatment... |
| Tipo: Journal article |
Palavras-chave: Chagas disease; Chemotherapy; Nifurtimox; Trypanosoma cruzi; Prostaglandins. |
| Ano: 2010 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000300009 |
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| STANLEY,DAVID W.; NOR ALIZA,A.R.; TUNAZ,HASAN; PUTNAM,SEAN M.; PARK,YOUNGJIN; BEDICK,JON C.. |
| Prostaglandins and related eicosanoids are oxygenated metabolites of certain C20 polyunsaturated fatty acids. Eicosanoids are best understood in the context of their clinical significance in human medicine. We suggest a new and broader view of eicosanoids, which we have been calling a 'biological paradigm'. Under this view, we note that eicosanoids were taken into roles as cellular signal moieties long before the origins of the Metazoa. During the evolutionary diversification of animals, eicosanoids have been recruited into an array of biological roles, some of which occur only in insects and other invertebrates. These multiple actions endow eicosanoids with unusual explanatory power in understanding biological phenomena. We review the roles of eicosanoids... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Insect immunity; Parasitology; Prostaglandins. |
| Ano: 2002 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-566X2002000300001 |
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| Seguineau, Catherine; Racotta, Ilie; Palacios, Elena; Delaporte, Maryse; Moal, Jeanne; Soudant, Philippe. |
| In a previous study, dietary supplementation with arachidonic acid (ARA) to oysters Crassostrea gigas increased haemocyte numbers, phagocytosis, and production of reactive oxygen species level (ROS) by haemocytes (Delaporte et al., 2006). To assess if the observed stimulation of these cellular responses resulted from changes of ARA-related prostaglandin (PG) production, we analysed prostaglandin E2 metabolite (PGEM) content on the same oysters fed three levels of ARA. Dietary supply of polyunsaturated fatty acids (PUFA) could also induce an oxidative stress that could similarly increase cellular responses; therefore, two indicators of oxidative stress were analysed: peroxidation level and antioxidant defence status. Together the observed positive... |
| Tipo: Text |
Palavras-chave: Prostaglandins; N-6 unsaturated fatty acids; Lipid peroxidation; Antioxidants; ROS production. |
| Ano: 2011 |
URL: http://archimer.ifremer.fr/doc/00040/15103/12785.pdf |
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